DNA photocleavage activity of cobalt(III) polypyridyl complexes containing dpq ligand |
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Authors: | Yi Sun Qian-Xiong Zhou Yuan-Jun Hou Xue-Song Wang Bao-Wen Zhang |
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Institution: | a Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China b Graduate School of Chinese Academy of Sciences, Beijing 100049, PR China |
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Abstract: | Four cobalt(III) polypyridyl complexes, Co(phen)3−n(dpq)n]3+ (phen = 1,10-phenanthroline, dpq = dipyrido3,2-f:2′,3′-h]-quinoxaline) (n = 0, 1, 2, and 3) were synthesized and the influences of the dpq ligand on the photophysical properties, electrochemical properties, DNA binding affinities, as well as photonuclease activities of the complexes, were examined in detail. The presence of dpq ligand increases the DNA binding affinities of the corresponding complexes remarkably with respect to Co(phen)3]3+. With the sequential substitution of phen ligand by dpq ligand, the 1O2 quantum yields of the corresponding complexes are enhanced greatly. As a result, the photonuclease activities follow the order of Co(dpq)3]3+ > Co(phen)(dpq)2]3+ > Co(phen)2(dpq)]3+ ? Co(phen)3]3+. It was found all the examined complexes can generate OH upon UV irradiation, and OH is also involved in DNA photocleavage as reactive oxygen species. |
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Keywords: | Cobalt(III) complexes dpq ligand DNA binding DNA photocleavage |
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