Attempt to detect recombination between B-F and B-L genes within the chicken B complex by serological typing,in vitro MLR,and RFLP analyses期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Attempt to detect recombination between B-F and B-L genes within the chicken B complex by serological typing,in vitro MLR,and RFLP analyses

Authors:	Karel Hála Anne-Marie Chaussé Yves Bourlet Olli Lassila Viktor Hasler Charles Auffray

Institution:	(1) Institute for General and Experimental Pathology, Medical School, University of Innsbruck, Innsbruck, Austria;(2) Institut d'Embryologie du CNRS et du Collège de France, Nogent s/Marne, France;(3) Basel Institute for Immunology, Basel, Switzerland

Abstract:	In search for recombinants within the chicken major histocompatibility B complex, 1155 animals from crosses between the congenic lines CB (B¹²) and CC (B⁴) were tested with alloantibodies and monoclonal antibodies for the B-F (class I), B-L (class II), and B-G (class IV) antigens and by mixed lymphocyte reaction. The absence of detectable recombination was confirmed by restriction fragment length polymorphism analysis with B-L and B-F probes. Together with previous reports, this indicates that the distance between the B-F and B-L loci is below 0.01 centimorgan.

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