Study on Omentin-1 and miR-502-3p in osteoporotic fracture |
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| Authors: | Jing Zhang Yun Hou Zhaoli Wang Peng Zhou Ping Zhang Jixian Wang Zhengang Sun Liyun Wang |
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| Institution: | 1.Specialist Clinic, Tai’an City Center Hospital, Shandong Province, China;2.Department of Surgery, Tai’an City Center Hospital, Shandong Province, China;3.Outpatient Department, Tai’an City Center Hospital, Shandong Province, China;4.Medical Centre, Tai’an City Center Hospital, Shandong Province, China;5.Huangdao District Central Hospital, Shandong Province, China |
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| Abstract: | Objectives:To explore the expression and correlation of Omentin-1 and miR-502-3p in serum of patients with osteoporotic fracture (OPF).Methods:Sixty OPF patients diagnosed and treated in our hospital from June 2018 to December 2019 were included in group A. Fifty-six osteoporosis patients without fractures were included in group B. Omentin-1 and miR-502-3p levels were detected by enzyme-linked immunosorbent assay (ELISA) and real-time quantitative PCR (qRT-PCR). Their predictive value for diagnostic efficiency was assessed by ROC curve. Spearman’s rank correlation test was used for correlation analysis. The risk factors related to the prognosis of OPF were analyzed by Logistic univariate and multivariate analysis.Results:The expression of Omentin-1 and miR-502-3p in group A was markedly lower than in group B (P<0.001). Spearman correlation analysis showed that in OPF, there was a negative correlation between serum Omentin-1 and TNF-α (r=0.8579, P<0.001), a negative correlation between serum miR-502-3p and TNF-α (r= 0.8653, P<0.001), and a positive correlation between serum Omentin-1 and miR-502-3p (r= 0.8764, P<0.001).Conclusions:Omentin-1 and miR-502-3p were down-regulated in serum of patients with OPF, both of which could be used as potential biomarkers for the diagnosis and disease evaluation of OPF. |
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| Keywords: | miR-502-3p Omentin-1 Osteoporotic Fracture Prognosis |
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