<Emphasis Type="Italic">In vitro</Emphasis> antileishmanial activity of <Emphasis Type="Italic">Aloe vera</Emphasis> leaf exudate: A potential herbal therapy in leishmaniasis |
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Authors: | Avijit Dutta Goutam Mandal Chitra Mandal Mitali Chatterjee |
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Institution: | (1) Department of Immunobiology, Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Jadavpur, Kolkata, 700 032, India;(2) Department of Pharmacology, Institute of Postgraduate Medical Education & Research, 244 B Acharya JC Bose Road, Kolkata, 700 020, India |
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Abstract: | Aloe vera has wide spread use in health products, and despite several reports on the whole plant and inner gel, little work has been
performed on the leaf exudate. Our aim was to evaluate the in vitro efficacy of Aloe vera leaf exudate (AVL) in leishmaniasis. Irrespective of the disease manifestation, promastigotes from strains responsible for
cutaneous, mucocutaneous, and visceral leishmaniasis were susceptible to AVL and their IC50 ranged from 100 to 180 μg/ml. In axenic amastigotes cultured from a L. donovani strain 2001 responsible for visceral leishmaniasis, the IC50 was 6.0 μg/ml. AVL caused activation of host macrophages evident by an increased release of members of reactive oxygen species
that was attenuated by preincubation with free radical scavengers. Collectively, our data indicates that AVL, via its direct
leishmanicidal activity which can be further enhanced by activation of host macrophages, is an effective antileishmanial agent
meriting further pharmacological investigations. |
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Keywords: | Aloe vera Leishmaniasis Antileishmanial Reactive oxygen species |
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