Liver microsomal membrane fluidity and lipid characteristics in vitamin A-deficient rats. |
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| Authors: | M W Hamm V Chan and G Wolf |
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| Institution: | Department of Nutrition, Rutgers University, New Brunswick, NJ 08903. |
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| Abstract: | Rat liver microsomes (microsomal fraction) were isolated from vitamin A-deficient and -sufficient rats and analysed for membrane lipid characteristics. Membrane fluidity was found to be significantly decreased in microsomes from the vitamin A-deficient rats, but not in liposomes prepared from lipid extracts. Microsomes from vitamin A-deficient animals showed a significant decrease in C18:2, omega 6 and an increase in C22:5, omega 6 fatty acids. |
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