C-myc expression is reduced in antipain-treated proliferating C3H 10T1/2 cells |
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| Authors: | J D Chang P C Billings A R Kennedy |
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| Affiliation: | 1. Department of Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy;2. Department of Information Engineering, Università Politecnica delle Marche, Ancona, Italy;4. Department of Electronics, Information and Biomedical engineering, Politecnico di Milano, Milan, Italy;5. Consiglio Nazionale delle Ricerche, Istituto di Elettronica e di Ingegneria dell''Informazione e delle Telecomunicazioni, Milan, Italy |
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| Abstract: | In this report, we demonstrate that treatment of proliferating irradiated and nonirradiated C3H 10T1/2 cells with the protease inhibitor antipain is associated with a reduction in c-myc expression. Under conditions in which antipain treatment results in reduced c-myc transcripts, there is no effect on total RNA synthesis, growth rate, or saturation density. Antipain may be a useful inhibitor in which to further study the role of c-myc in cellular physiology. |
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