|
|||||
|
|
Interaction Between Titanium and Cadmium in Various Guinea Pig Organs |
|
| Authors: | Takashi Takano Takeharu Kaneda Masaki Kaneshige Tomoko Tsutsumi Yoshitsugu Ochiai Kazumasa Shimizu Ryo Hondo Mariko Mochizuki Fukiko Ueda |
| Affiliation: | 1. Laboratory of Veterinary Public Health, School of Veterinary Medicine, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan, Musashino, Tokyo, 180-8602, Japan 2. Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan, Musashino, Tokyo, 180-8602, Japan 3. Department of Applied Science, School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan, Musashino, Tokyo, 180-8602, Japan |
| Abstract: | Titanium (Ti) is used in many fields, while cadmium (Cd) is known to cause the itai-itai disease. In the present study, possible interactions between titanium and cadmium were investigated. Aorta, taenia coli, and liver were removed from male guinea pigs. Muscle tension was measured using intact aorta and taenia coli and using β-escin-permeabilized taenia coli in a physiological salt solution and a hyperpotassium solution containing Cd and/or Ti. Cellular Cd contents were determined using all tissues after washout with EDTA solution. Cadmium-induced relaxation in the hyperpotassium solution recovered significantly (P?n?=?4) and 87.7?±?3.8 % (n?=?4), respectively, compared with Ca-induced control contraction. Cellular Cd contents in taenia coli decreased significantly following treatment with Ti 10?4?M. Although similar results were obtained using the aorta and the liver, there were no significant differences between the control and Ti 10?5?M. High concentrations of Ti may reduce cellular Cd content. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |