首页 | 本学科首页   官方微博 | 高级检索  
     


A sequence from drosophila DNA cross-hybridizing with a mouse class I H-2 Gene: absence of relevant nucleic acid or amino acid sequence homology
Authors:Alain Israel   Jean-Louis Becker   Odile Le Bail  Philippe Kourilsky
Affiliation:1. Unité de Biologie Moléculaire du Gène U277 INSERM associée au CNRS (UA 535) Institut Pasteur, 25 rue du Dr. Roux, 75724 Pairs Cedex 15, France
Abstract:Following serological data (1) showing cross-reactivity of drosophila surface antigens with anti-H-2 and mouse beta 2-microglobulin (beta 2-m) antisera, we have looked for homologous sequences in the drosophila genome by low stringency hybridization with mouse H-2 and beta 2-m probes. A 240 bp drosophila DNA segment cross-hybridizing with a H-2 probe, was isolated and sequenced. No homology at the nucleotide or amino acid levels was found with the mouse probe which was used, except for a perfectly matching 16-mer containing 11 G-C, which might be responsible for the cross-hybridization. Therefore, our present data do not support the existence of class I H-2 and/or beta 2-m related gene sequences in the drosophila genome.
Keywords:génome drosophile  séquences H-2 et β2-microglobuline de souris  hybridation à faible stringence  drosophila genome  mouse H-2 and β2-microglobuline sequences  low stringency hybridization
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号