Preliminary evaluation of pharmacological properties of some xanthone derivatives |
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| Authors: | Henryk Marona Natalia Szkaradek Anna Rapacz Barbara Filipek Małgorzata Dybała Agata Siwek Marek Cegła Edward Szneler |
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| Affiliation: | 1. Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Cracow, Poland;2. Department of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Cracow, Poland;3. Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Cracow, Poland;4. Laboratory of Pharmacologicall Screening, Faculty of Pharmacy, Jagiellonian University Medical College, Cracow, Poland;5. Department of Cytobiology and Histochemistry, Laboratory of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, Cracow, Poland;6. Faculty of Chemistry, Jagiellonian University, Cracow, Poland |
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| Abstract: | A series of xanthone derivatives were synthesized and examined for electrocardiographic, antiarrhythmic, hypotensive and anticonvulsant activities as well as for α1- and β1-adrenergic binding affinities. Among the investigated compounds, some of them exhibited significant antiarrhythmic and/or hypotensive activity. The data obtained via receptor binding assay are in agreement with pharmacological results and could explain antiarrhythmic and/or hypotensive activity of the newly synthesized structures. |
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