Identification of a bioactive compound isolated from Brazilian propolis type 6 |
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| Authors: | Myrella Lessio Castro Andréa Mendes do Nascimento Masaharu Ikegaki Cláudio M Costa-Neto Severino M Alencar Pedro L Rosalen |
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| Institution: | 1. Department of Physiological Sciences, Piracicaba Dental School, University of Campinas (UNICAMP), C.P. 52, 13414-903, Piracicaba, SP, Brazil;2. Department of Agri-Food Industry, Food and Nutrition, ‘Luiz de Queiroz’ College of Agriculture, University of Sao Paulo (USP), C.P. 9, 13418-900, Piracicaba, SP, Brazil;3. Department of Pharmacy, Federal University of Alfenas, Av. Gabriel Monteiro da Silva, 700, 37130-000, Alfenas, MG, Brazil;4. Department of Biochemistry and Immunology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo (USP), Av. Bandeirantes, 3900, 14049-900, Ribeirão Preto, SP, Brazil |
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| Abstract: | A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilian propolis type 6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC50 = 0.1756 μM), strong antimicrobial activity (MIC range—0.73–6.6 μg/mL; MBC range—2.92–106 μg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good. |
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