大鼠海马脑中枝形吊灯样中间神经元的形态与电生理学特征

在大鼠海马脑片标本上，用微电极记录并标记了４个枝形吊灯样中间，约占所记录到的３９个中间神经元的１０％，与蓝状中间神经元显著不同之处是，这４个神经元均对细胞内去极化电流表现出不同程度的放电频率适应现象，用细胞内注射ｂｉｏｃｙｔｉｎ的方法证实，蓝状中间神经元轴突终末主要分布在锥体在颗粒细胞层，与这些细胞胞体形成接触，而４个枝形吊灯样中间神经元的轴突终末增高度选择性分布在锥体和颗粒细胞轴突始段区，上述结

ELECTROPHYSIOLOGICAL CHARACTERISTICS OF MORPHOLOGICALLY IDENTIFIED CHANDELIER INTERNEURONS IN RAT HIPPOCAMPAL SLICES

Using standard intracellular recording and staining techniques,4 chandelier interneurons were sampled and anatomically confirmed from 39 physiologically identified interneurons in rat hippocampal slices.Compared to pyramidal and granule cells,all 4 chandelier interneurons(CAI region, n=3,dentate gyms,n=1)had typical action potentials of interneurons,i.e.,a shorter duration of action potential was followed by a deep after hyperpolarization.However,all these 4 cells exhibited a varying degree of spike frequency adaptation in response to depolarizing current injection, which usually do not occur in basket interneurons.Morphologically,a-conal terminals of chandelier cells were beaded and exclusively distributed in the stratum oriens of the CAI and the granule cell layer of the dentate gyms,where the initial segments of pyramidal and granule cells are located.These results indicate that the chandelier interneurons differ from basket interneurons in the rat hippocampus with in physiology and in morphology.