Suppression of angiotensin Ⅱ stimulated responses in aortic vascular smooth muscle cells of experimental cirrhotic rats |
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作者姓名: | ZHANG RU GUO LIANG WANG PI LI ZHANG YING XIONG WEN BO ZHANG XING PENG WANG DE LING YIN QING JING |
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作者单位: | ZHANG RU; GUO LIANG WANG; PI LI ZHANG;YING XIONG; WEN BO ZHANG; XING PENG WANG; DE LING YIN; QING JING (Shanghai Institute of Cell Biology,Chinese Academy of Sciences,320 Yue Yang Road,Shanghai 200031,China |
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摘 要: | INTRODUCTIONLivercirrhosisisoftencomplicatedbyhyperdynamiccirculation,whichischaracterizedbyadecreaseinarterialbloodpressureandperipheralvascularresistanceandanincreaseincardiacoutputandsplanchnicbloodnow1].Thesehaemodynamicdisturbancesareproposedtocontributetothedevelopmelltofportalhypertension,retentionofsodiumandwater,ascitesformationandcorrelatewithprognosisoflivercirrhosis2].Ithasbeensuggestedthatprimaryarterialvasodilationmayinducethishyperdynamiccirculation3].Buttheunderlyingmec…
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关 键 词: | Angiotensin Ⅱ aortic vascular smooth muscle cells cirrhosis receptor responses |
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