Effect of erythroid differentiation factor on megakaryocytic differentiation of L8057, a murine megakaryoblastic leukemia cell line. |
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| Authors: | M Nishimura K Kaku Y Azuno K Okafuji Y Etoh M Shiozaki H Sasaki T Inoue T Kaneko |
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| Institution: | Department of Pediatrics, Yokohama City University, School of Medicine, Japan. |
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| Abstract: | To assess the potent effect of erythroid differentiation factor (EDF) on megakaryocytopoiesis, effect of EDF on megakaryocytic differentiation of L8057, a murine megakaryoblastic cell line, was examined. EDF potentiated AchE induction of L8057 in a dose dependent manner. The potency of EDF on megakaryocytic differentiation is comparable to that on erythroid differentiation reported previously. The present results suggest that EDF may play a regulatory role in megakaryocytopoiesis as well as in erythropoiesis. |
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