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Synthesis and activity of novel bile-acid conjugated glucocorticoid receptor antagonists |
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| Authors: | Richards Steven J von Geldern Thomas W Jacobson Peer Wilcox Denise Nguyen Phong Ohman Lars Osterlund Marie Gelius Birgitta Grynfarb Marlena Goos-Nilsson Annika Wang Jiahong Fung Steven Kalmanovich Masha |
| Affiliation: | Metabolic Disease Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA. steven.richards@abbott.com |
| Abstract: | A series of potent steroidal glucocorticoid receptor antagonists has been discovered. After conjugation to cholic acid, the compounds retained an affinity for GR in vitro and had modest in vivo efficacy. |
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