| 肌动蛋白相关蛋白2/3复合体的结构、功能与调节 |
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| 引用本文： | Gong XW,Jiang Y. 肌动蛋白相关蛋白2/3复合体的结构、功能与调节[J]. 生理科学进展, 2004, 35(4): 306-310 |
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| 作者姓名： | Gong XW Jiang Y |
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| 作者单位： | 第一军医大学病理生理学教研室和广东省功能蛋白质组学重点实验室,广州,510515;第一军医大学病理生理学教研室和广东省功能蛋白质组学重点实验室,广州,510515;第一军医大学病理生理学教研室和广东省功能蛋白质组学重点实验室,广州,510515 |
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| 基金项目： | 国家杰出青年科学基金 (3992 5 0 14 ),国家自然科学基金重点项目 (30 0 30 0 6 0 )资助课题 |
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| 摘 要： | 微丝参与了细胞形态维持及细胞运动等多种重要的细胞过程。微丝由肌动蛋白单体组装而成 ,肌动蛋白相关蛋白 2 / 3(Arp2 /Arp3,Arp2 / 3)复合体在微丝形成过程中起重要作用。Arp2 / 3复合体由 7个亚单位组成 ,在细胞内受到多种核化促进因子的调节 ,并与这些因子协同作用来调节肌动蛋白的核化。Arp2 / 3复合体结构、功能及调节的研究对于阐明微丝形成机制及细胞骨架与某些信号分子的关系有重要意义。
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| 关 键 词： | 肌动蛋白相关蛋白2/3复合体 微丝 核化 核化促进因子 |
Structure, function and modulation of actin-related protein 2/3 complex |
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| Gong Xio-Wei,Jiang Yong. Structure, function and modulation of actin-related protein 2/3 complex[J]. Progress in Physiological Sciences, 2004, 35(4): 306-310 |
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| Authors: | Gong Xio-Wei Jiang Yong |
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| Affiliation: | Department of Pathophysiology of the First Military Medical University. |
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| Abstract: | Microfilaments, composed of global actins, i nvolve in many important physiological activities, such as the maintenance of ce ll shape and cell migration. Actin-related protein 2/3(Arp2/3)complex plays a key role in microfilament formation. Actin-related protein 2/3(Arp2/3)comple x which is composed of seven different subunits is subjected to the modulation o f many nucleation promoting factors (NPFs) and cooperates with these factors to regulate the actin nucleation. The study of the structure,function and modulati on of Arp2/3 complex is important in understanding the mechanism of the formatio n of microfilament and the interaction between cytoskeleton and signaling molecu les. |
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| Keywords: | Actin-related protein 2/3 complex Microf ilament Nucleation Nucleation promoting factor |
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