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Homeoviscous adaptation and its effect upon membrane-bound proteins |
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| Authors: | AR Cossins K Bowler CL Prosser |
| Institution: | a Dept. of Zoology, Univ. of Liverpool, Liverpool L69 3BX, U.K. b Dept. of Zoology, Univ. of Durham, Durham City DH1 3LE, U.K. c Dept. of Physiology and Biophysics, Univ. of Illinois, Urbana, Il, 61801, U.S.A. |
| Abstract: | Synaptic membranes of goldfish showed compensatory adjustments in fluidity when the fish were acclimated to high or low temperature. This was associated with changes in the thermal stability of the synaptic (Na++K+) ATPase at high inactivating temperatures. The importance of membrane fluidity to the structural stability of membrane-bound enzymes was supported by the labilising effects of the fluidising anaesthetic, n-hexanol, upon the (Na++K+) ATPase. These results indicate that homeoviscous adaptation elicits adaptive changes in the (Na++K+) ATPase. |
| Keywords: | Goldfish homeoviscous adaptation membrane fluidity (Na++K+) ATPase inactivation n-hexanol |
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