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The presence of antibodies against the AD2 epitope of cytomegalovirus glycoprotein B is associated with acute rejection after renal transplantation |
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| Authors: | Kei Ishibashi Tadahiko Tokumoto Hiroki Shirakawa Toshiki Oguro Tomohiko Yanagida Norio Takahashi Masanori Nomiya Nobuhiro Haga Ken Aikawa Kazunari Tanabe Naoki Inoue Yoshiyuki Kojima Tatsuo Suzutani |
| Institution: | 1. Department of Urology;2. Department of Microbiology, Fukushima Medical University, , Fukushima, 960‐1295;3. Department of Urology, Tokyo Women's Medical University, , Shinjuku‐ku, Tokyo, 162‐8666;4. Department of Virology I, National Institute of Infectious Diseases, , Toyama Shinjuku‐ku, Tokyo, 162‐8640 Japan |
| Abstract: | The aim of this study was to evaluate the association between antibodies against cytomegalovirus (CMV) glycoprotein B (gB) and acute rejection after transplantation. Seventy‐seven consecutive renal transplant recipients in a D + /R+ setting were studied. Biopsy‐proven rejection occurred in 35% of the recipients. Among these recipients, 85% had antibodies against CMV gB. The rate of acute rejection was significantly higher in recipients with antibodies against gB than in those without them. Antibodies against gB can be a useful predictor of acute rejection in renal transplant recipients in a D + /R+ setting. |
| Keywords: | acute rejection cytomegalovirus glycoprotein B renal transplantation |