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The Drosophila Tumorous lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus
Authors:William P. Hanratty and Charles R. Dearolf
Affiliation:(1) Department of Biological Sciences, University of Southern Mississippi, 39406 Hattiesburg, MS, USA;(2) Department of Radiation Oncology, Harvard Medical School, Dana Farber Cancer Institute, 02115 Boston, MA, USA;(3) Present address: Dana Farber Cancer Institute, Room JF 209, 44 Binney Street, 02115 Boston, MA, USA
Abstract:The Drosophila Tumorous-lethal (Tum-l) mutation acts as an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation. Tum-l is a dominant mutation in the hopscotch (hop) locus, which is required for cell division and for proper embryonic segmentation. The Tum-l temperature-sensitive period for melanotic tumor formation includes most of larval and pupal development.
Keywords:Drosophila melanogaster  Tumorous-lethal gene  hopscotch gene  Hematopoiesis
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