Benzodiazepine-based selective inhibitors of mitochondrial F1F0 ATP hydrolase |
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| Authors: | Hamann Lawrence G Ding Charles Z Miller Arthur V Madsen Cort S Wang Paulina Stein Philip D Pudzianowski Andrew T Green David W Monshizadegan Hossain Atwal Karnail S |
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| Institution: | Department of Discovery Chemistry, Bristol-Myers Squibb, Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ 08543-5400, USA. lawrence.hamann@bms.com |
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| Abstract: | A series of benzodiazepine-based inhibitors of mitochondrial F(1)F(0) ATP hydrolase were prepared and evaluated for their ability to selectively inhibit the enzyme in the forward direction. Compounds from this series showed excellent potency and selectivity for ATP hydrolase versus ATP synthase, suggesting a potentially beneficial profile useful for the treatment of ischemic heart disease. |
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