| 外源添加剂促进裂殖壶菌合成DHA |
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| 引用本文： | 王申强,罗玮,姜易彤,余晓斌.外源添加剂促进裂殖壶菌合成DHA[J].生物加工过程,2013(5):21-25. |
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| 作者姓名： | 王申强 罗玮 姜易彤 余晓斌 |
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| 作者单位： | 江南大学生物工程学院工业生物技术教育部重点实验室,无锡214122 |
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| 摘 要： | 为提高二十二碳六烯酸（DHA）产量,根据裂殖壶菌生物合成DHA的代谢途径,考察外源添加剂对裂殖壶菌发酵生产DHA影响。研究表明：分生物素、柠檬酸、苹果酸和洛伐他汀均能提高裂殖壶菌DHA的合成能力。同时添加生物素、苹果酸和洛伐他汀时能够显著提高DHA的产量,DHA的最高产量达到11.55 g/L,相比对照提高71.87%。
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| 关 键 词： | 裂殖壶菌 DHA 生物素 柠檬酸 苹果酸 洛伐他汀 |
Enhancing DHA synthesis in Schizochytrium limacinum by exogenous additives |
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| WANG Shenqiang,LUO Wei,JIANG Yitong,YU Xiaobin.Enhancing DHA synthesis in Schizochytrium limacinum by exogenous additives[J].Chinese Journal of Bioprocess Engineering,2013(5):21-25. |
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| Authors: | WANG Shenqiang LUO Wei JIANG Yitong YU Xiaobin |
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| Institution: | ( Key Laboratory of Industrial Biotechnology of the Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China) |
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| Abstract: | To improve the yield of docosahexaenoic acid （DHA）, effects of exogenous additives were investigated based on DHA synthetic metabolic pathway of Schizochytrium limacinum. Biotin, citric acid, malic acid, and lovastatin could independently improve the DHA yield of Schizochytrium limacinum. Moreover, when biotin, malie acid and lovastatin were added together, the maximum production of DHA reached 11.55 g/L, improved by 71.87% compared to the control group. |
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| Keywords: | Schizochytrium limacinum DHA biotin citric acid malie acid lovastatin |
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