The relationship between l-dopa decarboxylase in the latex of Papaver somniferum and alkaloid formation |
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| Authors: | Margaret F. Roberts Mikhail D. Antoun |
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| Affiliation: | Department of Pharmacognosy, The School of Pharmacy, London University, 29/39 Brunswick Square, London WC1N 1AX, U.K. |
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| Abstract: | The presence of l-dopa decarboxylase has been demonstrated in poppy latex utilising l-dopa-1-[14C] and l-dopa-3-[14Cl] as substrates. The enzyme appeared to have maximum activity at pH 7.2 and showed both substrate and pyridoxal phosphate inhibition. The substrates l-tyrosine, l-phenylalanine and l-histidine were also decarboxylated. l-dopa decarboxylase was found to occur solely in the latex supernatant fraction. The possible involvement of this enzyme in alkaloid biosynthesis in the latex is discussed. |
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| Keywords: | Papaveraceae alkaloid biogenesis secondary metabolism. |
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