Magnesium-deficiency elevates circulating levels of inflammatory cytokines and endothelin |
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Authors: | William B Weglicki Terry M Phillips Anthony M Freedman Marie M Cassidy Benjamin F Dickens |
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Institution: | (1) Department of Medicine, The George Washington University Medical Center, 20037 Washington DC, USA;(2) Department of Physiology, The George Washington University Medical Center, Room 402, Ross Hall, 2300 Eye Street NW, 20037 Washington DC, USA |
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Abstract: | Summary We have developed two rodent models of diet-induced magnesium-deficiency in which histologically defined cardiac lesions can
be induced within two to three weeks. During the development of these lesions, the magnesium-deficient animals exhibit circulating
cytokine levels which are indicative of a generalized inflammatory state. Dramatic elevations of the macrophage-derived cytokines,
IL-1, IL-6, and TNF-α together with signigicantly elevated levels of the endothelial cell-derived cytokine, endothelin, were
detected in the plasma of these animals. We believe that the pathophysiological effects caused by the action of these cytokines
may play a role in the promotion of cardiovascular pathology associated with magnesium deficiency. |
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Keywords: | cardiomyopathy TNF-α IL-1 IL-6 free radical mechanisms |
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