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Ultrastructure of the intestinal cells of Aspiculuris tetraptera after in vivo treatment of mice with mebendazole and thiabendazole
Authors:John C.W. Comley
Affiliation:Department of Zoology and Applied Entomology, Imperial College Field Station, Ashurst Lodge, Ascot, Berkshire, England
Abstract:Ultrastructural changes in the intestinal cells of female Aspiculuris tetraptera following in vivo treatment with mebendazole or thiabendazole are described. Major changes included a marked reduction in the luminal microbial flora and the appearance of large numbers of autophagic vesicles in the cytoplasm of the intestinal cells. Some mebendazole-treated nematodes were more severely affected, with a complete loss of cellular integrity and a collapse of the intestinal lumen. The possible role of the intestinal cell microtubules in inducing these anthelmintic effects is discussed.
Keywords:mice  electron microscopy  ultrastructure  intestinal cells  anthelmintics  mebendazole  thiabendazole
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