TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1 |
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| Authors: | Siddhartha P Sen Arrigo De Benedetti |
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| Affiliation: | (1) Department of Biochemistry and Molecular Biology and the Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130-3932, USA |
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| Abstract: | Background The mammalian protein kinase TLK1 is a homologue of Tousled, a gene involved in flower development in Arabidopsis thaliana. The function of TLK1 is not well known, although knockout of the gene in Drosophila, or expression of a dominant negative mutant in mouse mammary cells causes loss of nuclear divisions and chromosome mis-segregation. TLK1B is a splice variant of TLK1 and it confers radioresistance in a normal mammary mouse cell line possibly due to increased chromatin remodeling capacity, but the mechanism of resistance remains to be fully elucidated. |
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