Synthesis of enantiomerically pure milnacipran analogs and inhibition of dopamine, serotonin, and norepinephrine transporters |
| |
| Authors: | Roggen Heidi Kehler Jan Stensbøl Tine Bryan Hansen Tore |
| |
| Institution: | University of Oslo, Department of Chemistry, Sem Saelands vei 26, 0315 Oslo, Norway. |
| |
| Abstract: | A series of Milnacipran analogs with variation in the aromatic moiety were prepared in high enantiomeric excess. Structure-activity relationships for two parallel enantiomeric series are described. The (-)-(1R,2S)-naphthyl analog (8h) showed the highest potency in the two series and is a triple reuptake inhibitor of the SERT, NET, and DAT. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
