Differences in clinical manifestations of influenza-associated encephalopathy by age |
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Authors: | Tomoaki Wada Tsuneo Morishima Akihisa Okumura Masato Tashiro Mitsuaki Hosoya Masashi Shiomi Yoshinobu Okuno |
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Institution: | Department of Pediatrics, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama, 700-8558;;Department of Pediatrics and Adolescent Medicine, Juntendo University School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo, 113-8421;;Department of Virology III, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo, 162-8640;;Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima, 960-1295;;Department of Pediatric Emergency Medicine, Osaka City General Hospital, 2-13-22, Miyakojima-hondori, Miyakojima-ku, 534-0021;;Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, 3-69, Nakamichi 1-chome Higashinari-ku, Osaka, 537-0025, Japan |
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Abstract: | Data from patients in Japan was analyzed to examine the age distribution and differences by age in the clinical manifestations of influenza-associated encephalopathy. Between 1998 and 2002, 472 cases of influenza-associated encephalopathy in patients aged 15 years or younger were reported to the Collaborative Study Group on Influenza-Associated Encephalopathy. These cases were divided into two groups by age: 0–5 and 6–15 years. The differences between the groups were estimated based on the data for those aged 0–5 years, and the odds ratios and 95% confidence intervals calculated. Distribution was inversely correlated with age, with a peak at 1–2 years old. In comparison with patients aged 0–5, those aged 6–15 years had a significantly greater incidence of type B infection, lower frequency of convulsions, higher frequency of loss of consciousness and altered consciousness as the initial neurological symptom, lower serum transaminase levels, lower frequency of low-density area for brain CT upon admission, and lower incidence of sequelae. Our analysis indicates that the clinical course, laboratory data, and brain imaging findings of influenza-associated encephalopathy exhibits patterns that vary with age. |
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Keywords: | age distribution age groups influenza-associated encephalopathy |
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