Mathematical Modelling of Aerosolised Skin Grafts Incorporating Keratinocyte Clonal Subtypes |
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Authors: | Paula K. Denman D. L. Sean McElwain Damien G. Harkin Zee Upton |
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Affiliation: | (1) School of Mathematical Sciences, Queensland University of Technology, GPO Box 2434, Brisbane, 4001, Australia;(2) School of Life Sciences, Queensland University of Technology, GPO Box 2434, Brisbane, 4001, Australia |
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Abstract: | Severe burns can be very traumatic for the patient, and while burns caused by industrial or domestic accidents are common,
there are also increasing numbers of burns associated with terrorism. A novel technique to assist in the healing process is
to spray skin cells, keratinocytes, that are cultured from the patient’s own tissue, directly onto the burn site. This process
involves taking some undamaged skin from the patient, allowing the skin cells to proliferate rapidly in the laboratory over
a period of 5–10 days, harvesting and separating the cells and then spraying them onto the burn. This paper deals with keratinocytes
that have been cultured in vitro for a short period of time (early passage cultured cells). The spraying process has yet to
be optimised with respect to the seeding density required for fastest re-epithelisation and thus there is a need for this
process to be modelled. In this paper, we review some of the skin biology and develop a mathematical model of the growth patterns
of cell colonies after they have been applied using a aerosolised technique. The model allows us to predict coverage over
time and can be used as a decision support tool for clinicians.
PACS: 92B05 |
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Keywords: | Mathematical modelling Burns Skin Epidermis Keratinocytes Wound healing Clonal subtypes Stem cells Transient amplifying cells |
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