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Mathematical Modelling of Aerosolised Skin Grafts Incorporating Keratinocyte Clonal Subtypes
Authors:Paula K. Denman  D. L. Sean McElwain  Damien G. Harkin  Zee Upton
Affiliation:(1) School of Mathematical Sciences, Queensland University of Technology, GPO Box 2434, Brisbane, 4001, Australia;(2) School of Life Sciences, Queensland University of Technology, GPO Box 2434, Brisbane, 4001, Australia
Abstract:Severe burns can be very traumatic for the patient, and while burns caused by industrial or domestic accidents are common, there are also increasing numbers of burns associated with terrorism. A novel technique to assist in the healing process is to spray skin cells, keratinocytes, that are cultured from the patient’s own tissue, directly onto the burn site. This process involves taking some undamaged skin from the patient, allowing the skin cells to proliferate rapidly in the laboratory over a period of 5–10 days, harvesting and separating the cells and then spraying them onto the burn. This paper deals with keratinocytes that have been cultured in vitro for a short period of time (early passage cultured cells). The spraying process has yet to be optimised with respect to the seeding density required for fastest re-epithelisation and thus there is a need for this process to be modelled. In this paper, we review some of the skin biology and develop a mathematical model of the growth patterns of cell colonies after they have been applied using a aerosolised technique. The model allows us to predict coverage over time and can be used as a decision support tool for clinicians. PACS: 92B05
Keywords:Mathematical modelling  Burns  Skin  Epidermis  Keratinocytes  Wound healing  Clonal subtypes  Stem cells  Transient amplifying cells
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