| 线粒体H^＋-ATPase超分子结构及其催化机制的研究现状 |
| |
| 引用本文： | 朱杰,;郭连红,;张斌,;贺道华,;王国栋.线粒体H^＋-ATPase超分子结构及其催化机制的研究现状[J].生物磁学,2008(12):2556-2561. |
| |
| 作者姓名： | 朱杰 ;郭连红 ;张斌 ;贺道华 ;王国栋 |
| |
| 作者单位： | [1]西北农林科技大学理学院,陕西杨凌712100; [2]西北农林科技大学生命科学院,陕西杨凌712100; [3]西北农林科技大学农学院,陕西杨凌712100; [4]陕西师范大学应用声学研究所,陕西西安710062 |
| |
| 基金项目： | 西北农林科技大学人才基金项目（01140501）和国家自然科学基金项目（20572067）致谢：感谢美国Argonne国家实验室的IrvingT.C.教授和BureaR.A.研究员的指导以及陕西师范大学孙润广教授、齐浩教授的有益探讨.感谢胡静硕士和朱华泽同学在资料搜集中所作的贡献. |
| |
| 摘 要： | 质子泵H^＋-ATPase广泛存在于线粒体,叶绿体,异养菌和光合细菌中,是生物体能量转换的核心酶,有极为重要的生理作用。近几年来,对H^＋-ATPase的结构、功能和调控机制的研究进展很快,对复合体的组装有了进一步的认识。对H^＋-ATPase的主要亚基已经完成序列测定及分析,对各亚基生理功能也进行了较为深入的研究。生物化学及分子生物学工作揭示：生物体内以多种方式对编码H^＋-ATPase主要亚基的基因表达和该酶的活力进行调控。其中,对于线粒体H^＋-ATPasc的研究显得尤为突出。本文综述了线粒体H^＋-ATPase的结构、功能、和调节方面的研究现状,并进一步提出了一些值得深入探讨的问题。
|
| 关 键 词： | 线粒体 H^+-ATPase F1F0-ATPase 超微观结构 催化机制 水解作用 合成作用 |
Status Quo in the Ultrastructure and Catalysis Mechanism of the Mitochondrial H^＋ -ATPase |
| |
| Institution: | ZHU Jie, Guo Lian-hong, ZHANG Bin, He Dao-hua, Wang Guo-dong (1. College of Science, Northwest A＆F University, Yangling, 712100 China; 2. College of Life Science, Northwest A＆F University, Yangling, 712100 China; 3. College of Agriculture, Northwest A＆F University, Yangling, 712100 China; 4. Institute of Applied Acoustics, Shaanxi Normal University, Xi ＇an, 710062 China ) |
| |
| Abstract: | nd bovine heart mitochondria,which catalyses the transformation between ATP and ADP＆Pi by using the energy of electrochemical proton gradient derived from electron transport. In the past several years, the progress of the study on the enzyme is rapid and we have known much more about the structure, function and the reconstitution of the ATP synthase. The work of biochemistry and molecularbiology in the enzyme has recovered the subunits and its function of the H＋ -ATPase, at the same time, we have built the catalysis mechanism of synthase. This paper has summarized the variety development of the mitochondrial ATPase, and put forward several questions for discussion. |
| |
| Keywords: | Mitochondria H＋ -ATPase F1F0-ATPase Catalysis mechanism Hydrolysis Ultrafine structure Synthesis |
| 本文献已被 维普 等数据库收录！ |
|
