运用系统论原理复制人类疾病动物模型

依据系统论的基本原理,人类疾病动物模型采用整体设计,统筹考虑模型与实验动物生物学特性方面的相似性、模型复制的重复性、可靠性、适用性、可控性、易行性和经济性等,以便模型复制的顺利开展。整体性原则应贯穿整个模型复制过程,使复制的模型具有科学性和实用性。模型复制要落实系统论的相关性原则,一个模型不是孤立的,动物的各系统、各器官、各分子之间是相互联系,人类和动物在生物学、解剖学、组织学、胚胎学、生理学、病理学等方面的相互联系,疾病的发生、发展是相互联系的,相关性原则为动物模型研究人类疾病提供了理论依据。动物模型在时间和空间上处于不断运动变化发展之中,在研究模型的过程中,要用动态的方法而不是静止的方法来研究动物模型,应根据疾病的特点,分成不同的阶段,结合动物的免疫功能、营养状况、疾病的发展、转归等采用不同的对策。模型的复制采用最优化原则,要求模型设计最优化,选用高质量的实验动物,减少动物使用数量,保护动物福利与伦理,最终实现模型评价体系的最优化。

Replication of Animal Models of Human Diseases by System Theory

According to the basic principles of system theory,animal models of human diseases were designed integrally.In order to replicate successfully,consideration should be taken on comparability of biological characteristics of the animal models,and the repeatability,credibility ,applicability,controllability,maneuverability and economy,etc.of animal models.The integration principle should run through the whole model replication process,making the replicated model scientific and functional.The model replication should be carried out in accordance with correlation principle of system theory.A model isn＇t isolated from systems,organs,and molecules each other.The mankind and animals are closely correlated mutually in biology,anatomy,histology,embryology,physiology,pathology...etc. The disease occurrence and development are related mutually,and the correlation principle makes the animal models useful in research of human diseases.Animal models are developing constantly in time and space.Animal models should be studied dynamically according to the immune function,nutritional condition,pathogenesis and outcome of the animal disease,etc. Optimization principle for animal models include appropriate experimental design and application of high quality animals,reduce the number of used animals,protecting animal welfare,and to comply the ethic principles.Therefore,a model evaluation system is optimized finally.