Rat cerebral endothelial cells express trk C and are regulated by neurotrophin-3 |
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Authors: | Takeo Chikari Nakamura Susumu Tanaka Tomoaki Uchida Daigaku Noguchi Yoshihiko Nagao Toshitaka Saito Yasushi Tatsuno Ichiro |
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Institution: | The Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuou-ku, Chiba-city, 260-8655, Chiba, Japan. |
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Abstract: | Cerebral endothelial cells (CEC) are critical for formation of the vascular system in the mammalian central nervous system (CNS). We focused on the neurotrophin (NT) for its possible involvement in signaling for the regulation of CEC to control formation and maintenance of the vascular system in CNS in comparison of rat cerebral endothelial cells (RCEC) with rat aortic endothelial cells (RAEC). We found that (1) trk C, a receptor for neurotrophin-3 (NT-3), is dominantly expressed in RCEC, but trk B, a receptor for brain-derived neurotrophic factor, is dominantly expressed in RAEC; (2) NT-3 inhibited the proliferation of RCEC; and (3) NT-3 stimulated the production of nitric oxide (NO) with increases in protein expression of endothelial NO synthase. These data indicated that NT may regulate and/or maintain the functions of the brain microvasculature through the regulation of CEC. |
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Keywords: | Cerebral endothelial cells Neurotrophin Trk Proliferation Nitric oxide |
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