Synthesized esters of ferulic acid induce release of cytochrome c from rat testes mitochondria |
| |
Authors: | E Cione P Tucci V Senatore M Perri S Trombino F Iemma N Picci G Genchi |
| |
Institution: | (1) Dipartimento Farmaco-Biologico, Laboratorio di Biochimica, Edificio Polifunzionale, Università della Calabria, 87036 Rende, CS, Italy;(2) Dipartimento di Scienze Farmaceutiche, Laboratorio di Chimica Organica, Edificio Polifunzionale, Università della Calabria, 87036 Rende, CS, Italy |
| |
Abstract: | Ferulic acid plays a chemopreventive role in cancer by inducing tumor cells apoptosis. As mitochondria play a key role in
the induction of apoptosis in many cells types, here we investigate the mitochondrial permeability transition (MPT) and the
release of cytochrome c induced by ferulic acid and its esters in rat testes mitochondria, in TM-3 and MLTC-1 cells. While ferulic acid, but not
its esters, induced MPT and cytochrome c release in rat testes isolated mitochondria, in TM-3 cells we found that both ferulic acid and its esters induced cytochrome
c release from mitochondria in a dose-dependent manner, suggesting a potential target of these compounds in the induction of
cell apoptosis. The apoptosis induced by ferulic acid is therefore associated with the mitochondrial pathway involving cytochrome
c release and caspase-3 activation.
Cione and Tucci have equally contributed to this article. |
| |
Keywords: | Ferulic acid Cytochrome c Apoptosis Mitochondria TM-3 cells MLTC-1 cells |
本文献已被 PubMed SpringerLink 等数据库收录! |
|