Reestablishment of self tolerance by suppressor T-cells after active Heymann's nephritis |
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| Authors: | E de Heer M R Daha J Burgers L A van Es |
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| Affiliation: | 1. Department of Medical Biology, Faculty of Medicine, Yozgat Bozok University, Yozgat, Turkey;2. Department of Histology and Embryology, Faculty of Medicine, Yozgat Bozok University, Yozgat, Turkey;3. Department of Agricultural Biotechnology, Faculty of Agriculture, Erciyes University, Kayseri, Turkey;1. School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, No. 232 Outer Ring Road, Panyu District, Guangzhou, Guang Dong 510006, China;2. The First School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, China;3. School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China |
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| Abstract: | ![]()
Adoptive transfer experiments were performed to obtain evidence that the down-regulation of the autoimmune response in rats with active Heymann's nephritis (HN) is due to suppressor T cells. Late in the course of HN antigen-specific OX8+ suppressor T cells were found in the spleen, but never in the draining lymph nodes. These cells were shown to suppress the autoimmune response when transferred to naive recipients that were subsequently challenged. By mixing B cells or helper T cells from rats with HN with suppressor T cells from high-dose tolerant rats we showed that OX8+ suppressor T cells appeared to have a direct suppressive effect on autoreactive B cells. A profound suppressive effect on helper T cells appeared after 10 weeks. Possible mechanisms to account for the failure of Lewis rats to maintain self tolerance are discussed. |
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