| V型H+-ATPase结构和调控机制的研究现状 |
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| 引用本文： | 祝雄伟,王延枝,王欢.V型H+-ATPase结构和调控机制的研究现状[J].生物化学与生物物理进展,1999,26(4):323-327. |
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| 作者姓名： | 祝雄伟 王延枝 王欢 |
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| 作者单位： | 武汉大学生命科学学院,武汉,430072 |
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| 基金项目： | 国家自然科学基金资助项目(39570434). |
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| 摘 要： | V-ATPase存在于所有已知的真核生物中，有极为重要的生理作用.近几年来，对V-ATPase的结构、功能和调控机制的研究进展很快，对复合体的组装有了进一步的认识.对V-ATPase的主要亚基已经完成序列测定及分析，对各亚基生理功能也进行了较为深入的研究.生物化学及分子生物学工作揭示：生物体内以多种方式对编码V-ATPase主要亚基的基因表达和该酶的活力进行调控.
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| 关 键 词： | V-ATPase，结构，调控 |
| 收稿时间： | 5/7/1998 12:00:00 AM |
| 修稿时间： | : 1998-05- |
Progress on the Strcture and Regulation of V-ATPase |
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| ZHU Xiong-Wei,WANG Yan-Zhi and WANG Huan.Progress on the Strcture and Regulation of V-ATPase[J].Progress In Biochemistry and Biophysics,1999,26(4):323-327. |
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| Authors: | ZHU Xiong-Wei WANG Yan-Zhi and WANG Huan |
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| Institution: | College of Life Science, Wuhan University, Wuhan 430072, China;College of Life Science, Wuhan University, Wuhan 430072, China;College of Life Science, Wuhan University, Wuhan 430072, China |
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| Abstract: | V-ATPase is present in every known eukaryotic cell and plays a vital role. The study on the structure, function, assembly and the regulation of V-ATPase has achieved much progress recently. All the core subunits of V-ATPase have now been sequenced and most of their functions have been assigned to some extent. Membrane biochemistry and molecular biology studies discovered that the gene expression and the activity of V-ATPase are regulated in various ways. |
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| Keywords: | V-ATPase structure regulation |
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