| 新型抗高血压活性肽GAP-A的一级结构及生理活性研究 |
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| 引用本文： | 宫霞,王兰芳,郭本恒.新型抗高血压活性肽GAP-A的一级结构及生理活性研究[J].氨基酸和生物资源,2009,31(3):1-6. |
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| 作者姓名： | 宫霞 王兰芳 郭本恒 |
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| 作者单位： | 上海商学院食品学院,上海,200235;同济大学基础医学院,上海,200092;光明乳业股份有限公司技术中心,上海,200072 |
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| 基金项目： | 上海市教委创新项目 |
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| 摘 要： | 研究了新型乳酪蛋白源抗高血压活性肽GAP-A的分子量与一级结构,并检测了其对体外血管紧张素转化酶(ACE)的抑制活性及体内降血压效果。结果显示:抗高血压活性肽GAP-A分子量为M2,氨基酸序列为B1-B2-B3;GAP-A在体外对ACE有很强的抑制活性,抑制率为79.6%;GAP-A对自发性高血压大鼠(spontaneously hypertensive rats,SHR)有显著的降血压作用,而对血压正常的SD大鼠的血压没有影响。
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| 关 键 词： | 抗高血压活性肽 一级结构 血管紧张素转化酶 血压 |
Study on Primary structure and Physiological Activites of New Antihypertensive Tripeptide GAP-A from Casein |
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| GONG Xia,WANG Lan-fang,GUO Beng-heng.Study on Primary structure and Physiological Activites of New Antihypertensive Tripeptide GAP-A from Casein[J].Amino Acids & Biotic Resources,2009,31(3):1-6. |
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| Authors: | GONG Xia WANG Lan-fang GUO Beng-heng |
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| Institution: | GONG Xia1,WANG Lan-fang2,GUO Beng-heng3(1.Department of Food Science,Shanghai Business School,Shanghai 200235,2.School of medicine,Tongji University,Shanghai 200092,3.Bright Dairy Technical Center,Shanghai 200072,China) |
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| Abstract: | Molecular wight and primary structure of new antihypertensive tripeptide GAP-A from casein and its hypertensive effect in vitro-vivo were investigated.The result of amino acid analysis showed that the molecule weight and the sequence of GAP-A were M2 and B1-B2-B3 respectively.ACE inhibitory activity and antihypertensive activity of tripeptide GAP-A were measured.The results showed that tripeptide GAP-A(50μg/mL) had significant inhibitory activity against ACE(the inhibitory rate 79.6%),the dosage of 5mg/kg of body weight every day) had remarkable antihypertension on SHR,but it was no use for SD rats. |
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| Keywords: | antihypertensive peptides primary structure ACE blood pressure |
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