Resistance to cell-mediated cytotoxicity is correlated with reduction of H-2K gene products in AKR leukemia |
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Authors: | Wilhelm Schmidt Hilliard Festenstein |
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Institution: | (1) Institut für Virologie, Justus-Liebig-Universität Gießen, D-6300 Giessen, Germany;(2) Department of Immunology, The London Hospital Medical College, London, UK |
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Abstract: | AKR leukemia cell lines differing in the amount of H-2K and H-2D antigens expressed on the cell surface were used to assess cell-mediated immune responses in syngeneic mice against Gross/AKR murine leukemia virus (MuLV)-induced tumors. Leukemic cells with reduced expression of H-2Kk antigens were inactive as inducers of Gross-MuLV/H-2k-specific cytotoxic T lymphocytes (CTL) and resistant to lysis by CTL raised against H-2Kk positive AKR leukemia cells. H-2Kk positive leukemias induced cytotoxic effectors, which upon restimulation in vitro, lysed the stimulating and other H-2Kk positive leukemia cells. In antibody inhibition experiments, T-cell-mediated cytotoxicity to these leukemias could only be inhibited by antisera and monoclonal antibodies specific for the H-2Kk antigens. Due to this specific role of H-2Kk antigens in T-cell cytotoxicity to Gross/AKR MuLV-induced tumors, reduced expression of H-2Kk antigens on spontaneous AKR leukemic cells could have important implications for surveillance of these neoplastic cells.Abbreviations used in this paper CTL
cytotoxic T lymphocytes
- MuLV
murine leukemia virus |
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