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Mapping and characterization of the origin of DNA replication of porcine circovirus. |
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| Authors: | A Mankertz F Persson J Mankertz G Blaess and H J Buhk |
| Abstract: | The origin of DNA replication of porcine circovirus (PCV) was mapped to a 111-bp fragment. On top of a hairpin, a nonanucleotide (TAGTATTAC) homologous to nonanucleotides of other viruses was identified. Mutation of this element abolishes replication. PCV may be related to a virus family characterized by single-stranded circular DNA genomes, rolling-circle replication, and homology of their rep proteins. |
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