Enhanced uridine kinase and RNA synthesis in regenerating rat liver after 5-azacytidine administration |
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Authors: | Alois ?ihákMarie Seifertová Ji?í veselý |
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Institution: | Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Prague 6, Czechoslovakia |
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Abstract: | The administration of 5-azacytidine to partially hepatectomized rats results in the increase of uridine kinase activity in cell-free liver extracts 24–72 hr after drug administration. At the same time the activity of uridine phosphorylase and of uridine 5′-nucleotidase is decreased, while uridinemonophosphate kinase and uridine 5′-triphosphatase are not affected. The repeated administration of 5-azacytidine leads to a further enhancement of uridine kinase which is 6- to 8-fold higher in 96-hr regenerating livers than in untreated controls. Simultaneously the enhanced incorporation of uridine into liver ribonucleic acids was observed. The metabolic alterations occurring in the liver at later phases after 5-azacytidine in vivo administration are discussed. |
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