| 左旋多巴甲酯缓释微球的研究 |
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| 引用本文： | 任甜甜郑瑞媛胡振华蔡云鹏陈晓静朱涵蕾袁伟恩.左旋多巴甲酯缓释微球的研究[J].现代生物医学进展,2011,11(11):2034-2036. |
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| 作者姓名： | 任甜甜郑瑞媛胡振华蔡云鹏陈晓静朱涵蕾袁伟恩 |
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| 作者单位： | 上海交通大学,上海,200240 |
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| 基金项目： | 国家重大专项-"重大新药创制"科技重大专项-创新药物研究开发技术平台，上海科委项目，上海交通大学大学生创新项目 |
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| 摘 要： | 目的:由于长期服用左旋多巴治疗帕金森病,其药物浓度波动刺激易引起异动症,本实验旨在制备突释小,药物释放浓度稳定的左旋多巴甲酯微球制剂。方法:将左旋多巴甲酯用复乳法包裹于PLGA微球内,采用C18反相色谱研究药物包封率和体外释放行为。结果:通过调节药物浓度和不同高分子组合筛选出突释小,包封率高且缓慢释放的处方。结论:左旋多巴甲酯包裹于PLGA能实现理想的缓释效果,降低药物浓度波动,为后期药效学实验提供基础。
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| 关 键 词： | 左旋多巴甲酯 PLGA微球 缓释 帕金森氏病 异动症 |
Research of Levodopa Methyl Ester-loaded Microspheres Delivery System |
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| REN Tian-tian,ZHENG Rui-yuan,HU Zhen-hu,CAI Yun-peng,CHEN Xiao-jing,ZHU Han-lei,YUAN Wei-en.Research of Levodopa Methyl Ester-loaded Microspheres Delivery System[J].Progress in Modern Biomedicine,2011,11(11):2034-2036. |
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| Authors: | REN Tian-tian ZHENG Rui-yuan HU Zhen-hu CAI Yun-peng CHEN Xiao-jing ZHU Han-lei YUAN Wei-en |
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| Institution: | △(Shanghai Jiao Tong University,Shanghai 200240) |
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| Abstract: | Objective: Chronic administration of levodopa in the treatment of PD leads to debilitated involuntary movements,we aimed to prepare levodopa methyl ester-loaded sustained release microspheres without initial burst.Methods: Levodopa methyl ester(LDME) were microencapsulated into PLGA microspheres by multiple emulsion technique.The encapsulation efficiency and vitro release of microspheres were detected using HPLC system equipped with a C18 reverse column.Results: By adjusting LDME concentra-tion and differen... |
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| Keywords: | LDME PLGA microspheres Sustained release Parkinson's disease Levodopa-induced dyskinesia |
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