Effects of decreased glutathione peroxidase activity on the pentose phosphate cycle in mouse lung |
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| Authors: | Nabil Elsayed Allen Hacker Mohammad Mustafa Klaus Kuehn Gerhard Schrauzer |
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| Institution: | 1. School of Public Health, University of California, Los Angeles, USA;2. School of Medicine, University of California, Los Angeles, USA;3. Department of Bioinorganic Chemistry, University of California, San Diego, USA |
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| Abstract: | The effects of reducing glutathione peroxidase activity in the lung by changing dietary selenium intake has been investigated. In animals that were exposed to room air, selenium effects were confined to glutathione peroxidase activity, whereas under conditions of oxidant stress (ozone) the decrease in glutathione peroxidase activity prevented the stimulation of the pentose phosphate cycle (assayed by measuring glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase activities) which has been reported to increase in response to oxidant stress. The suppression of glutathione peroxidase activity was found to depend on dietary selenium concentration. The physiological significance of this observation may be related to the process of injury and repair in the lung. |
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