Estradiol receptors in articular chondrocytes |
| |
| Authors: | Itzhak A. Rosner Andrea Manni Charles J. Malemud Beata Boja Roland W. Moskowitz |
| |
| Affiliation: | 1. Cartilage Research Laboratory Department of Medicine Case Western Reserve University School of Medicine Cleveland, Ohio 44106 USA;2. Division of Endocrinology Department of Medicine Case Western Reserve University School of Medicine Cleveland, Ohio 44106 USA |
| |
| Abstract: | Recent experimental studies suggest a role for estrogens in chondrocyte metabolism and the development and treatment of osteoarthritis. Type I cytoplasmic estradiol receptors were found in articular chondrocytes. The presence of these receptors supports a possible mechanism for previous observations on estrogen suppressive effects on cartilage proteoglycan synthesis and offers a basis for further study on the role of estrogens in the physiology of cartilage and in the pathogenesis and treatment of osteoarthritis. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
