Alterations in DNA-dependent RNA polymerase I from rat liver accompanying ethionine administration |
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| Authors: | Haruko Yamano Yasuko Sawai Wen Long Thung Fumiyasu Sato Kinji Tsukada |
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| Affiliation: | Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, Kandasurugadai, Chiyoda-ku, Tokyo 101, Japan |
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| Abstract: | Multiple injections of ethionine plus adenine resulted in 3- to 4-fold increases in the activity of RNA polymerase I from rat liver nuclei, whereas the activity of RNA polymerase II was relatively unaffected. Methyl-deficient preribosomal RNA was present in the livers of rats after treatment for 2 days. Both incorporation of labelled orotate into rat liver ribosomal RNA and protein synthesis in polysomes gradually increased. |
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| Keywords: | tRNA transfer RNA rRNA ribosomal RNA |
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