Cholesterol as a target for toxins |
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| Authors: | B de Kruijff |
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| Institution: | (1) Centre for Biomembranes and Lipid Enzymology and Institute of Molecular Biology and Medical Biotechnology, University of Utrecht, Padualaan 8, 3584 CH Utrecht, NL |
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| Abstract: | A mechanism is proposed for the way in which cholesterol facilitates channel formation by polyene antibiotics and bacterial protein toxins. Central elements of the model are: (i) interactions between the ring system of the sterol and rigid elements of the polyene or toxin molecule, and (ii) the specific orientation of cholesterol within the membrane. |
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| Keywords: | polyene antibiotics bacterial protein toxins channel formation cholesterol |
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