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Memory CD4+ T Lymphocytes in the Gastrointestinal Tract Are a Major Source of Cell-Associated Simian Immunodeficiency Virus in Chronic Nonpathogenic Infection of African Green Monkeys |
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| Authors: | Joern E. Schmitz Zhong-Min Ma Emily A. Hagan Andrew B. Wilks Kathryn L. Furr Caitlyn H. Linde Roland C. Zahn Jason M. Brenchley Christopher J. Miller Sallie R. Permar |
| Affiliation: | aDivision of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA;bCenter for Comparative Medicine;cCalifornia National Primate Research Center, University of California, Davis, California, USA;dLaboratory of Molecular Microbiology and Program in Barrier Immunity and Repair, NIAID, NIH, Bethesda, Maryland, USA;eHuman Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA |
| Abstract: | Simian immunodeficiency virus (SIV) infection of natural hosts is characterized by nonpathogenic chronic viremia, maintenance of gastrointestinal epithelial barrier integrity, and low numbers of target cells. Assessment of cell-associated virus load in T cell subsets in multiple anatomic compartments of chronically SIV-infected sabeus African green monkeys (AGMs) revealed that gastrointestinal memory CD4+ T lymphocytes are a major source of cell-associated virus and a significant contributor to SIV viremia in AGMs. |
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