Opium Addiction Increases Interleukin 1 Receptor Antagonist (IL-1Ra) in the Coronary Artery Disease Patients |
| |
| Authors: | Habibollah Saadat Seyed Ali Ziai Maryam Ghanemnia Mohammad Hasan Namazi Morteza Safi Hosein Vakili Ali Dabbagh Omid Gholami |
| |
| Institution: | 1. Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; 2. Pharmacology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Evin, Tehran, Iran.; 3. Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Sapienza University of Rome, Italy, |
| |
| Abstract: | BackgroundThere is evidence that opium addiction has immunosuppressant effects. Coronary artery disease (CAD) is a condition resulted from atherosclerosis which is dependent on the immune response.PurposeTo evaluate plasma levels of interleukin-6 and interleukin-1Ra in 30 patients with three-vessel coronary artery disease, ejection fraction of more than 35% and to evaluate their changes after prognostic treadmill test in 15 opium addicted and 15 non-addicted patients.MethodsThe participants underwent prognostic treadmill test and plasma levels of interleukin-6 (IL-6) and interleukin-1Ra (IL-1Ra) were evaluated with ELISA method before, just after and 4 hours after the test.ResultsIL-1Ra (2183 pg/ml) tended to decrease over time in the opium addicted group (1372 pg/ml after prognostic treadmill test and 1034 pg/ml 4 hours after that), although such decrease did not reach the statistical significance. IL-1Ra levels were significantly higher in opium addicted than in non addicted patients. Opium addiction had no significant effect on IL-6 changes.ConclusionConsumption of opium in CAD patients is associated with higher IL-1Ra levels. |
| |
| Keywords: | |
|
|
