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Dinorcassane Diterpenoid from Boesenbergia rotunda Rhizomes Collected in Lower Myanmar
Authors:Nwet Nwet Win  May Mon Kyaw  Prema  Hla Ngwe  Takuya Ito  Yoshinori Asakawa  Yasuko Okamoto  Masami Tanaka  Ikuro Abe  Hiroyuki Morita
Abstract:A new dinorcassane diterpenoid, seikphoochinal A ( 1 ), and four known compounds, pinostrobin ( 2 ), 4′,7‐dimethylkaempferol ( 3 ), and galanals A ( 4 ) and B ( 5 ), were isolated from the chloroform‐soluble crude extract of wild type Boesenbergia rotunda rhizomes collected in Lower Myanmar. The chemical structures of these compounds were identified, using a combination of spectroscopic methods. The presence of the diterpenoids 1 , 4 , and 5 demonstrated the structural diversity of wild type B. rotunda. Among the isolates, compounds 4 and 5 exhibited significant antiproliferative activities against a small panel of human cancer cell lines, including lung (LK‐2, A549), stomach (ECC4), breast (MCF7), cervix (HeLa), and prostate (DU145).
Keywords:Boesenbergia rotunda  dinorcassane diterpenoid  seikphoochinal A  antiproliferative activity  biological activity  phytochemistry
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