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Comparison of Variable-Number Tandem-Repeat Markers typing and IS1245 Restriction Fragment Length Polymorphism fingerprinting of Mycobacterium avium subsp. hominissuis from human and porcine origins |
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| Authors: | Taneli Tirkkonen Jaakko Pakarinen Elina Rintala Terhi Ali-Vehmas Harri Marttila Olli AT Peltoniemi and Johanna M?kinen |
| Institution: | (1) Faculty of Veterinary Medicine, Department of Production Animal Medicine, University of Helsinki, POB 66, FIN 00014 Helsinki, Finland;(2) A-Farmers Ltd, POB 910, FIN 60061 Atria, Finland;(3) Faculty of Agriculture and Forestry, Department of Applied Chemistry and Microbiology, University of Helsinki, Helsinki, Finland;(4) Faculty of Veterinary Medicine, Department of Basic Veterinary Sciences, University of Helsinki, POB 56, FIN 00014 Helsinki, Finland;(5) Mycobacterial Reference Laboratory, The National Institute for Health and Welfare, Kiinanmyllynkatu 13, FIN 20520 Turku, Finland;(6) Lieto municipality, Po box 24, FIN 21421 Lieto, Finland |
| Abstract: | BackgroundAnimal mycobacterioses are regarded as a potential zoonotic risk and cause economical losses world wide. M. avium subsp. hominissuis is a slow-growing subspecies found in mycobacterial infected humans and pigs and therefore rapid and discriminatory typing methods are needed for epidemiological studies. The genetic similarity of M. avium subsp. hominissuis from human and porcine origins using two different typing methods have not been studied earlier. The objective of this study was to compare the IS1245 RFLP pattern and MIRU-VNTR typing to study the genetic relatedness of M. avium strains isolated from slaughter pigs and humans in Finland with regard to public health aspects. |
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