Ultraviolet radiation, weather and the blood levels of 25-hydroxyvitamin D

Assays of plasma levels of 25-hydroxyvitamin D are widely used to assess vitamin D nutrition in health and disease. In interpreting the results it is important to take into account not only details of analytical technique but also environmental conditions including latitude, season, occupation and weather. This paper presents new data which show that climatic variations from year to year may make appreciable differences to the reference ranges which are appropriate for the interpretation of results from patients.