HLA Class I and Class II Associations with ESRD in Saudi Arabian Population |
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| Authors: | Nuha Mahmoud Hamdi Fadel Hassan Al-Hababi Amr Ekhlas Eid |
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| Institution: | 1. Immunology Department, Riyadh Regional Laboratory, King Saud Medical Complex, Riyadh, Kingdom of Saudi Arabia.; 2. Virology Department, Riyadh Regional Laboratory, King Saud Medical Complex, Riyadh, Kingdom of Saudi Arabia.; 3. Nephrology Department, Riyadh Medical Complex, King Saud Medical Complex, Riyadh, Kingdom of Saudi Arabia.; Temple University School of Medicine, United States of America, |
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| Abstract: | BackgroundChronic renal failure (CRF) leads in the majority of instances to end stage renal disease (ESRD) requiring renal replacement therapy. Our interest was to evaluate the possible associations of HLA class I and class II antigens with ESRD independent of other factors, in Saudi Arabia population.MethodologyA retrospective study to determine the HLA class I and class II polymorphisms and their association with ESRD, was performed on 350 patients with ESRD, and 105 healthy unrelated control. Patients and control groups were typed by SSOP lumenix techniques. The alleles positively associated to the ESRD were: HLA-B*15, B*18, B*49 - DRB1*03, negatively associated alleles were A*26, HLA-B*39, B*50. The haplotypes positively associated with ESRD were: HLA-A*01-DRB1*13 and HLA-A*30-DRBI*03. The negatively associated haplotypes were: HLA-A*02-B*39, A*02-B*50, A*24-B*35, A*24-B*58, A*24-DRB1*16, A*68-DRB1*04, A*02-DQB1*03, A*29-DQB1*02, A*29-DOB1*05 and B*27-DRB1*07 and the last one is the most significant protective haplotypes.ConclusionThe high Relative Risk (RR) observed and its statistical correlation reflect the strength of the described association between HLA antigens and ESRD. |
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