response of relaxin-treated rat uterus to prostaglandins and oxytocin |
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Authors: | WA Chamley MM Bagoyo GD Bryant-Greenwood |
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Institution: | 1. Pacific Biomedical Research Center, USA;2. Department of Anatomy & Reproductive Biology University of Hawaii Honolulu, Hawaii 96822, USA |
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Abstract: | Paired segments of rat uterus were treated with relaxin (W1164-3, 150 GPU/mg) until the amplitude of contraction was reduced to at least 50% of the pre-treatment amplitude. Test segments then received 100 ng of either PGE1, PGE2, PGF2α or 250 uU of oxytocin. Control segments remained untreated. There was a significant increase in contraction amplitude in response to the spasmogens (P < 0.05) but no increase was seen in controls. |
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