Recent evolutionary history of American Onchocerca volvulus, based on analysis of a tandemly repeated DNA sequence family |
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Authors: | Zimmerman PA; Katholi CR; Wooten MC; Lang-Unnasch N; Unnasch TR |
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Institution: | Department of Medicine, University of Alabama at Birmingham 35294. |
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Abstract: | Polymerase chain reaction (PCR) products were characterized for a repeated
sequence family (designated "O-150") of the human filarial parasite
Onchocerca volvulus. In phylogenetic inferences, the O-150 sequences
clustered into closely related groups, suggesting that concerted evolution
maintains sequence homology in this family. Using a novel mathematical
model based on a nested application of an analysis of variance, we
demonstrated that African rainforest and savannah strain parasite
populations are significantly different. In contrast, parasites collected
in the New World are indistinguishable from African savannah strains of O.
volvulus. This finding supports the hypothesis that onchocerciasis was
recently introduced into the New World, possibly as a result of the slave
trade.
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